Orfadin

Product Description

WHAT ARE THE INDICATIONS?

Heriditary tyrosinemia type (HT-1) – adjunct to dietary reduction of tyrosine and phenylamine in
the treatment of HT-1

WHAT ARE THE DOSAGES?

• Dose should be adjusted in each patient.
• The recommended initial dosage is 1mg/kg/day divided for morning and evening administration.
  Since the effect of food is unknown , nitisone should be taken at least 1 hour before a meal.

PATIENT INFORMATION:

1. Advice patients and their caregivers of the need to maintain dietary resriction of tyrosine and
phenylalanine when taking nitisinone to treat HT-1
2. Advice patients and their caregivers to promptly report unexplained eye symptoms , rash,
jaundice, oe excessive bleeding